Perhaps the worst pickup line I've ever heard:
Guy to girl: "Are your parents retarded?"
Girl (offended and confused) to guy: "No, why would you say that? [while she thinks to herself, now this is one sick, sad, pathetic fucker.]"
Guy to girl: "Because you seem really special."
*This was taken from a clip of a new, gasp, MTV show. Who'd a thunk it?